Recent Publications


Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity
HJ Lee, L Min, J Gao, S Matta, V Drel, A Saliba, I Tamayo, R Montellano, …
Diabetes, db230807

Spatial N-glycomics with MALDI-MSI for human kidney tissue
D Velickovic, K Sharma, T Alexandrov, C Anderton

In-Vivo Anti-diabetic activity of Leonotis nepetaefolia (L.) R. Br. Root in Alloxan induced Diabetic Model
S Dwivedi, A Chandekar, A Tripathi, R Mishra, M Chhajed, K Sharma, …
NATURALISTA CAMPANO 28 (1), 2190-2193

Wcn24-606 Proteomic Analysis Uncovers New Circulating Proteins Associated With Incident Hypertension Over 15 Years In Youth With Type 2 Diabetes
P Narongkiatikhun, YJ Choi, K Tommerdahl, K Sharma, S Waikar, …
Kidney International Reports 9 (4), S322-S323

Urine Tricarboxylic Acid Cycle Metabolites and Risk of End-stage Kidney Disease in Patients With Type 2 Diabetes
JJ Liu, S Liu, H Zheng, J Lee, RL Gurung, C Chan, LS Lee, K Ang, …
The Journal of Clinical Endocrinology & Metabolism, dgae199

Understanding Heterogeneity in Individual Responses to Digital Lifestyle Intervention Through Self-Monitoring Adherence Trajectories in Adults With Overweight or Obesity …
S Li, Y Du, H Miao, K Sharma, C Li, Z Yin, B Brimhall, J Wang
Journal of Medical Internet Research 26, e53294

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making.
N Ragi, K Sharma
American Journal of Nephrology

Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project
TM El-Achkar, MT Eadon, M Kretzler, J Himmelfarb, B Lake, K Zhang, …
American Journal of Kidney Diseases 83 (3), 402-410

Interactive Effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals With Type 1 Diabetes
L Kugathasan, VS Sridhar, LE Lovblom, S Matta, A Saliba, S Debnath, …
Diabetes 73 (3), 401-411

In Memoriam of William Lloyd Henrich, MD, MACP
K Sharma, J Reiser, OW Moe, WB Reeves
Journal of the American Society of Nephrology, 10.1681

Decoding Heterogeneity in Data-Driven Self-Monitoring Adherence Trajectories in Digital Lifestyle Interventions for Weight Loss: A Qualitative Study
S Li, Y Du, C Meireles, D Song, K Sharma, Z Yin, B Brimhall, J Wang

Nurse-in-the-Loop Artificial Intelligence for Precision Management of Type 2 Diabetes in a Clinical Trial Utilizing Transfer-Learned Predictive Digital Twin
SHA Faruqui, A Alaeddini, Y Du, S Li, K Sharma, J Wang
arXiv preprint arXiv:2401.02661

Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial
PK Judge, N Staplin, KJ Mayne, C Wanner, JB Green, SJ Hauske, …
The Lancet Diabetes & Endocrinology 12 (1), 51-60

Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the EMPA-KIDNEY trial
N Staplin, R Haynes, PK Judge, C Wanner, JB Green, J Emberson, …
The Lancet Diabetes & Endocrinology 12 (1), 39-50

Ketone production and excretion even during mild hyperglycemia and the impact of sodium-glucose co-transporter inhibition in type 1 diabetes
D Scarr, E Lovblom, H Ye, H Liu, A Bakhsh, NJ Verhoeff, TMS Wolever, …
Diabetes Research and Clinical Practice 207, 111031

The Relationship Of Self-Monitoring Of Lifestyles With Physical Function And Metabolites In Diabetic Older Adults
Y Du, L Song, M Gonzales, S Espinoza, C Jaen, J Wang, K Sharma
Innovation in Aging 7 (Supplement_1), 869-869

Plasma tryptophan-kynurenine pathway metabolites and risk for progression to end-stage kidney disease in patients with type 2 diabetes
JJ Liu, J Ching, HN Wee, S Liu, RL Gurung, J Lee, H Zheng, LS Lee, …
Diabetes Care 46 (12), 2223-2231

Metabolomic profiles associated with physical activity in White and African American adult men
Y Du, YY Li, BY Choi, R Fernadez, KJ Su, K Sharma, L Qi, Z Yin, Q Zhao, …
PloS one 18 (11), e0289077

Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients
K Sharma, G Zhang, J Hansen, P Bjornstad, HJ Lee, R Menon, L Hejazi, …
The Journal of Clinical Investigation 133 (20)

Metabolic Differences in Diabetic Kidney Disease Patients with Normoalbuminuria versus Moderately Increased Albuminuria
SI Hallan, MA Øvrehus, M Darshi, D Montemayor, KA Langlo, P Bruheim, …
Kidney360 4 (10), 1407-1418

Improving the performance of optoelectronic devices using hexabutyloxytriphenylene-based discotic mesogens as an interfacial layer
DP Singh, A Shah, M Depriester, AK Srivastava, P Prajongtat, S Kumar
Optics of Liquid Crystals (OLC)-2023

Adherence to ketogenic diet in lifestyle interventions in adults with overweight or obesity and type 2 diabetes: a scoping review
S Li, Y Du, C Meireles, K Sharma, L Qi, A Castillo, J Wang
Nutrition & Diabetes 13 (1), 16

9-OR: Insulin Resistance (IR) and Kidney Oxidative Metabolism in People with Type 1 Diabetes (T1D)
Diabetes 72 (Supplement_1)

1096-P: Plasma Metabolites Predict Loss of Glycemic Control in Youth with Type 2 Diabetes (T2D)
Diabetes 72 (Supplement_1)

406-P: Spatial Metabolomics of Human Kidney Tissues Reveal Impaired Tricarboxylic Acid (TCA) Cycle Turnover in Type 1 Diabetes (T1D)
G Zhang, L Liu, IM Tamayo, N GARCIA PONCE DE LEON, TB Vigers, …
Diabetes 72 (Supplement_1)

12-OR: Urine Lactate Is a Disease Biomarker for Diabetic Kidney Disease
Diabetes 72 (Supplement_1)

400-P: Spatial Metabolomics Analysis by MSI-DeepPath Identifies Key Pathways in ZDF Diabetic Kidney Disease Model
Diabetes 72 (Supplement_1)

1095-P: Proteomic Analyses Identify Novel Predictors of Loss of Glycemic Control in Youth-Onset Type 2 Diabetes
Diabetes 72 (Supplement_1)

316-OR: ADA Presidents’ Select Abstract: Structural Lesions on Kidney Biopsy in Youth-Onset Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)
Diabetes 72 (Supplement_1)

317-OR: Metabolomic Analyses Identify Novel Predictors of Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes
Diabetes 72 (Supplement_1)

Development of a definition of postacute sequelae of SARS-CoV-2 infection
T Thaweethai, SE Jolley, EW Karlson, EB Levitan, B Levy, GA McComsey, …
Jama 329 (22), 1934-1946

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome
M Ge, J Molina, JJ Kim, SK Mallela, A Ahmad, JV Santos, H Al-Ali, …
Elife 12, e83353

Tryptophan metabolites and anemia in patients with diabetic kidney disease. J Debnath S, Thomas N, Saliba A, Kottewar S, Grant S, Kasinath BS, Sharma K, Lorenzo C. Nephrol. 2023 May;36(4):1083-1085. doi: 10.1007/s40620-023-01620-0. Epub 2023 Apr 10. PMID: 37036660.

TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury. Das, F., Ghosh-Choudhury, N., Maity, S., Kasinath, B.S. and Ghosh Choudhury, G. (2023), FEBS Lett, 597: 1300-1316.

Psychometric Properties of the Brief Fatigue Inventory in Hemodialysis Patients during a Dialysis Day: A Preliminary Report. Debnath S, Rueda R, Thomas N, Kottewar S, Grant S, Lorenzo C. Clin Nurs Res. 2023 Mar;32(3):445-451. doi: 10.1177/10547738221149811. Epub 2023 Jan 23. PMID: 36688335.

Empagliflozin in Patients with Chronic Kidney Disease. The EMPA-KIDNEY Collaborative Group; Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R. N Engl J Med. 2023 Jan 12;388(2):117-127. doi: 10.1056/NEJMoa2204233. Epub 2022 Nov 4. PMID: 36331190; PMCID: PMC7614055.

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome Ge, M., Molina, J., Kim, J.J., Mallela, S.K., Ahmad, A., Santos, J.V., Al-Ali, H., Mitrofanova, A., Sharma, K., Fontanesi, F. and Merscher, S., 2023.. Elife, 12, p.e83353.

Crabtree effect in kidney proximal tubule cells via late-stage glycolytic intermediates. Darshi, M., Tumova, J., Saliba, A., Kim, J., Baek, J., Pennathur, S. and Sharma, K., 2023. Iscience, 26(4).

Tryptophan metabolites and anemia in patients with diabetic kidney disease. Debnath, S., Thomas, N., Saliba, A., Kottewar, S., Grant, S., Kasinath, B.S., Sharma, K. and Lorenzo, C., 2023. Journal of Nephrology, pp.1-3.

Role of Kynurenine/Tryptophan Ratio in Kidney-Lung crosstalk in two porcine trauma-induced multi-organ injury models. Singh, P., Montemayor, D., Pamreddy, A., Drel, V., Ye, H., Franzone, A., Zang, Y., Roberts, T., Chung, K., Batchinsky, A. and Sharma, K., 2023. 332 Journal of Clinical and Translational Science, 7(s1), pp.99-99.

A generalized covariate-adjusted top-scoring pair algorithm with applications to diabetic kidney disease stage classification in the Chronic Renal Insufficiency Cohort (CRIC) Study. Kwan, B., Fuhrer, T., Montemayor, D., Fink, J.C., He, J., Hsu, C.Y., Messer, K., Nelson, R.G., Pu, M., Ricardo, A.C. and Rincon-Choles, H., 2023. BMC bioinformatics, 24(1), p.57.

Examining the Individual Response to a Low-Sodium Diet in Patients with Hypertension: Protocol for a Pilot Randomized Controlled Trial. Ko, J., Wang, J., Chung, M.L. and Sharma, K., 2023. JMIR Research Protocols, 12(1), p.e39058.

Exploration and analysis of R-loop mapping data with RLBase. Miller, H.E., Montemayor, D., Li, J., Levy, S.A., Pawar, R., Hartono, S., Sharma, K., Frost, B., Chedin, F. and Bishop, A.J., 2023. Nucleic acids research, 51(D1), pp.D1129-D1137.

Role of endogenous adenine in kidney failure and mortality with diabetes. Sharma, K., Zhang, G., Hansen, J., Bjornstad, P., Lee, H.J., Menon, R., Hejazi, L., Liu, J.J., Franzone, A., Looker, H.C. and Choi, B.Y., 2023. medRxiv, pp.2023-05.

Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis. Das F, Ghosh-Choudhury N, Maity S, Kasinath BS, Choudhury GG. J Biol Chem. 2022 Sep;298(9):102246. doi: 10.1016/j.jbc.2022.102246. Epub 2022 Jul 11. PMID: 35835217; PMCID: PMC9399488.

Corrigendum to: Marmoset as a Model to Study Kidney Changes Associated With Aging. Lee HJ, Gonzalez O, Dick EJ, Donati A, Feliers D, Choudhury GG, Ross C, Venkatachalam M, Tardif SD, Kasinath BS. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):84. doi: 10.1093/gerona/glab238. Erratum for: J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):315-324. PMID: 34542600; PMCID: PMC8915215.

Alkyl-substituted N-methylaryl-N’-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase. Robello M, Zheng H, Saha M, George Rosenker KM, Debnath S, Kumar JP, Tagad HD, Mazur SJ, Appella E, Appella DH. Eur J Med Chem. 2022 Dec 5;243:114763. doi: 10.1016/j.ejmech.2022.114763. Epub 2022 Sep 18. PMID: 36179402; PMCID: PMC9664485.

Transcriptional regulation by a RecQ helicase. Methods Enzymol. Debnath S, Lu X, Sharma S. 2022;673:227-249. doi: 10.1016/bs.mie.2022.03.057. Epub 2022 Apr 18. PMID: 35965009; PMCID: PMC9379128.

Genome-wide investigations on regulatory functions of RECQ1 helicase. Methods. Debnath S, Lu X, Lal A, Sharma S. 2022 Aug;204:263-268. doi: 10.1016/j.ymeth.2022.02.010. Epub 2022 Feb 26. PMID: 35231585; PMCID: PMC9233132.

Multi-scalar data integration links glomerular angiopoietin-tie signaling pathway activation with progression of diabetic kidney disease. Liu, J., Nair, V., Zhao, Y.Y., Chang, D.Y., Limonte, C., Bansal, N., Fermin, D., Eichinger, F., Tanner, E.C., Bellovich, K.A. and Steigerwalt, S., 2022. Diabetes71(12), pp.2664-2676.

Spatial N-glycomics with MALDI-MSI for human kidney tissue. D Velickovic, K Sharma, T Alexandrov, C Anderton. 202 DOI:

Enhanced spatial mapping of histone proteoforms in human kidney through MALDI-MSI by high-field UHMR-orbitrap detection. Zemaitis, K.J., Veličković, D., Kew, W., Fort, K.L., Reinhardt-Szyba, M., Pamreddy, A., Ding, Y., Kaushik, D., Sharma, K., Makarov, A.A. and Zhou, M., 2022. Analytical chemistry94(37), pp.12604-12613.

A technology assisted precision ketogenic diet intervention for cardio-renal-metabolic health in overweight or obese adults: Protocol for a randomized controlled trial. Du, Y., Wang, J., Li, S., Dennis, B., Meireles, C., Siddiqui, N., Patel, D., Gelfond, J., Li, C., Alaeddini, A. and Drel, V., 2022. Contemporary Clinical Trials119, p.106845.

Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions. Miller, H.E., Montemayor, D., Abdul, J., Vines, A., Levy, S.A., Hartono, S.R., Sharma, K., Frost, B., Chédin, F. and Bishop, A.J., 2022. Nucleic acids research50(13), pp.7260-7286.

Controlled humidity levels for fine spatial detail information in enzyme-assisted N-glycan MALDI MSI. Velickovic, D., Sharma, K., Alexandrov, T., Hodgin, J.B. and Anderton, C.R., 2022. Journal of the American Society for Mass Spectrometry33(8), pp.1577-1580.

A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project. Butler, C.R., Appelbaum, P.S., Ascani, H., Aulisio, M., Campbell, C.E., de Boer, I.H., Dighe, A.L., Hall, D.E., Himmelfarb, J., Knight, R. and Mehl, K., 2022. American Journal of Kidney Diseases80(1), pp.132-138.

A reference tissue atlas for the human kidney. Hansen, J., Sealfon, R., Menon, R., Eadon, M.T., Lake, B.B., Steck, B., Anjani, K., Parikh, S., Sigdel, T.K., Zhang, G. and Velickovic, D., 2022. Science advances8(23), p.eabn4965.

Urinary proteomics identifies cathepsin D as a biomarker of rapid eGFR decline in type 1 diabetes. Limonte, C.P., Valo, E., Drel, V., Natarajan, L., Darshi, M., Forsblom, C., Henderson, C.M., Hoofnagle, A.N., Ju, W., Kretzler, M. and Montemayor, D., 2022. Diabetes care45(6), pp.1416-1427.

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation. Menon, R., Bomback, A.S., Lake, B.B., Stutzke, C., Grewenow, S.M., Menez, S., D’Agati, V.D., Jain, S., Knight, R., Lecker, S.H. and Stillman, I., 2022. Kidney international101(6), pp.1116-1125.

Spatial metabolic profiling of Alzheimer disease and glioma. Walker, J., Pamreddy, A., Ghamasaee, P., Burket, A., Bieniek, K., Seshadri, S., Sharma, K. and Richardson, T., 2022, May. In JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (Vol. 81, No. 6, pp. 463-463). JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA: OXFORD UNIV PRESS INC.

A review of extracorporeal blood purification techniques for the treatment of critically ill coronavirus disease 2019 patients. Niazi, N.S., Nassar, T.I., Stewart, I.J., Honore, P.M., Sharma, K. and Chung, K.K., 2022. Asaio Journal68(10), p.1219.

A multicenter evaluation of the seraph 100 microbind affinity blood filter for the treatment of severe COVID-19. Chitty, S.A., Mobbs, S., Rifkin, B.S., Stogner, S.W., Lewis, M.S., Betancourt, J., DellaVolpe, J., Abouzahr, F., Wilhelm, A.M., Szerlip, H.M. and Parikh, A., 2022. Critical Care Explorations4(4).

An adverse outcomes approach to study the effects of SARS-CoV-2 in 3D organoid models. Basu, A., Pamreddy, A., Singh, P. and Sharma, K., 2022. Journal of Molecular Biology434(3), p.167213.

Role of matrix assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI): A novel tool to study bioenergetic signature in kidney cancer. Garg, H., Pamreddy, A., Hejazi, L., Montemayor, D., Ding, Y., Venkatachalam, M.A., Sharma, K. and Kaushik, D., 2022, February. In EUROPEAN UROLOGY (Vol. 81, pp. S1654-S1655). RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS: ELSEVIER.

Empagliflozin reduces renal lipotoxicity in experimental Alport syndrome. Ge, M., Molina, J., Kim, J.J., Mallela, S.K., Ahmad, A., Varona Santos, J., Al-Ali, H., Mitrofanova, A., Sharma, K., Fontanesi, F. and Merscher, S., 2022. bioRxiv, pp.2022-10.

RLSuite: An integrative R-loop bioinformatics framework. Miller, H.E., Montemayor, D., Levy, S.A., Sharma, K., Frost, B. and Bishop, A.J., 2022. bioRxiv, pp.2022-07.

Cardiac Safety in Breast Cancer Patients Receiving Pegylated Liposome Doxorubicin Sequential Anti-HER2 Monoclonal Antibody Therapy. Huang, P., Huang, J.H., Zheng, Y.B., Cao, W.M., Shao, X.Y., Chen, J.Q., Huang, Y., Li, G.L., Sharma, K., Zhou, H.H. and Wang, X.J., 2022. Frontiers in Pharmacology13, p.883600.

High-throughput metabolomics and diabetic kidney disease progression: evidence from the chronic renal insufficiency (CRIC) study. Zhang, J., Fuhrer, T., Ye, H., Kwan, B., Montemayor, D., Tumova, J., Darshi, M., Afshinnia, F., Scialla, J.J., Anderson, A. and Porter, A.C., 2022. American journal of nephrology53(2-3), pp.215-225.

Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury. Lee, H. J., Mariappan, M. M., Norton, L., Bakewell, T., Feliers, D., Oh, S. B., Donati, A., Rubannelsonkumar, C. S., Venkatachalam, M. A., Harris, S. E., Rubera, I., Tauc, M., Ghosh Choudhury, G., Kahn, C. R., Sharma, K., DeFronzo, R. A., & Kasinath, B. S. (2021). JCI insight, 6(3), e143619.

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project.” El-Achkar, Tarek M., Michael T. Eadon, Rajasree Menon, Blue B. Lake, Tara K. Sigdel, Theodore Alexandrov, Samir Parikh, Guanshi Zhang, Dejan Dobi, Kenneth W. Dunn, Edgar A. Otto, Christopher R. Anderton, Jonas M. Carson, Jinghui Luo, Chris Park, Habib Hamidi, Jian Zhou, Paul Hoover, Andrew Schroeder, Marianinha Joanes, Evren U. Azeloglu, Rachel Sealfon, Seth Winfree, Becky Steck, Yongqun He, Vivette D’Agati, Ravi Iyengar, Olga G. Troyanskaya, Laura Barisoni, Joseph Gaut, Kun Zhang, Zoltan Laszik, Brad H. Rovin, Pierre C. Dagher, Kumar Sharma, Minnie M. Sarwal, Jeffrey B. Hodgin, Charles E. Alpers, Matthias Kretzler, and Sanjay Jain. Physiological Genomics 53.1 (2021): 1-11.

Temporal Telomere and DNA Damage Responses in the Space Radiation Environment. Jared J. Luxton, Miles J. McKenna, Lynn E. Taylor, Kerry A. George, Sara R. Zwart, Brian E. Crucian, Viktor R. Drel, Francine E. Garrett-Bakelman, Matthew J. Mackay, Daniel Butler, Jonathan Foox, Kirill Grigorev, Daniela Bezdan, Cem Meydan, Scott M. Smith, Kumar Sharma, Christopher E. Mason, Susan M. Bailey. Cell Reports, Volume 33, Issue 10, 2020, 108435, ISSN 2211-1247.

A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes. Limonte, C. P., Valo, E., Montemayor, D., Afshinnia, F., Ahluwalia, T. S., Costacou, T., Darshi, M., Forsblom, C., Hoofnagle, A. N., Groop, P. H., Miller, R. G., Orchard, T. J., Pennathur, S., Rossing, P., Sandholm, N., Snell-Bergeon, J. K., Ye, H., Zhang, J., Natarajan, L., de Boer, I. H., … Sharma, K. (2020). American journal of nephrology, 51(10), 839–848.

Gut Microbial Changes in Diabetic db/db Mice and Recovery of Microbial Diversity upon Pirfenidone Treatment. Singh, H., Miyamoto, S., Darshi, M., Torralba, M. G., Kwon, K., Sharma, K., & Pieper, R. (2020). Microorganisms, 8(9), 1347.

Storage Conditions of Human Kidney Tissue Sections Affect Spatial Lipidomics Analysis Reproducibility. Jessica K. Lukowski, Annapurna Pamreddy, Dusan Velickovic, Guanshi Zhang, Ljiljana Pasa-Tolic, Theodore Alexandrov, Kumar Sharma, Christopher R. Anderton. Journal of the American Society for Mass Spectrometry 2020 31 (12), 2538-2546. DOI: 10.1021/jasms.0c00256

A role for tubular Na+/H+ exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin. Onishi, A., Fu, Y., Patel, R., Darshi, M., Crespo-Masip, M., Huang, W., Song, P., Freeman, B., Kim, Y. C., Soleimani, M., Sharma, K., Thomson, S. C., & Vallon, V. (2020). American journal of physiology. Renal physiology, 319(4), F712–F728.

Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis. Kawanishi, K., Saha, S., Diaz, S., Vaill, M., Sasmal, A., Siddiqui, S. S., Choudhury, B., Sharma, K., Chen, X., Schoenhofen, I. C., Sato, C., Kitajima, K., Freeze, H. H., Münster-Kühnel, A., & Varki, A. (2021). The Journal of clinical investigation, 131(5), e137681.

Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity. Neeharika Nemani, Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, Karthik Ramachandran, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya Singhmalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Christopher E. Shannon, Warren G. Tourtellotte, Brij B. Singh, W. Brian Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Jonathan Soboloff, Muniswamy Madesh. Science Signaling21 Apr 2020.

Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Farsad Afshinnia, Lixia Zeng, Jaeman Byun, Stefanie Wernisch, Rajat Deo, Jing Chen, Lee Hamm, Edgar R Miller, Eugene P Rhee, Michael J Fischer, Kumar Sharma, Harold I Feldman, George Michailidis, Subramaniam Pennathur, the CRIC Study Investigators, Nephrology Dialysis Transplantation, Volume 35, Issue 2, February 2020, Pages 303312.

Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study. Brian Kwan, Tobias Fuhrer, Jing Zhang, Manjula Darshi, Benjamin Van Espen, Daniel Montemayor, Ian H. de Boer, Mirela Dobre, Chi-yuan Hsu, Tanika N. Kelly, Dominic S. Raj, Panduranga S. Rao, Santosh L. Saraf, Julia Scialla, Sushrut S. Waikar, Kumar Sharma, Loki Natarajan, Lawrence J. Appel, Harold I. Feldman, Alan S. Go, Jiang He, James P. Lash, Mahboob Rahman, Raymond R. Townsend. American Journal of Kidney Diseases, Volume 76, Issue 4, 2020, Pages 511-520, ISSN 0272-6386.

DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules. Zhang, G., Zhang, J., DeHoog, R.J. et al.  Metabolomics 16, 11 (2020).

Storage Conditions of Human Kidney Tissue Sections Affect Spatial Lipidomics Analysis Reproducibility. Jessica K. Lukowski, Annapurna Pamreddy, Dusan Velickovic, Guanshi Zhang, Ljiljana Pasa-Tolic, Theodore Alexandrov, Kumar Sharma, Christopher R. Anderton. Journal of the American Society for Mass Spectrometry 2020 31 (12), 2538-2546. DOI: 10.1021/jasms.0c00256

Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue. Debnath S., Lorenzo C., Bansal S., Morales J., Rueda R.O., Kasinath B.S., Sharma K., O’Connor J.C. Am J Nephrol 2020; 51: 565 – 571.

Assessment of fatigue in hemodialysis patients: Performance of the Brief Fatigue Inventory. Debnath, S., Rueda, R., Bansal, S., Sharma, K., & Lorenzo, C. (2021). General hospital psychiatry, 68, 115–117.

Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes. Jennifer Concepcion, Katherine Chen, Rintaro Saito, Jon Gangoiti, Eric Mendez, Maria Eleni Nikita, Bruce A. Barshop, Loki Natarajan, Kumar Sharma, Jane J. Kim. PLoS One, June 2020. DOI 10.1371/journal.pone.0234970

Comparative genomics and diversity of SARS-CoV-2 suggest potential regional virulence. Sundru Manjulata Devi, Annapurna Pamreddy, Balakuntalam Kasinath, Kumar Sharma. Research Square. 2020. DOI:

mGWAS: next generation genetic prediction in kidney disease. Montemayor, D., Sharma, K. Nat Rev Nephrol 16, 255–256 (2020).

Towards Building a Smart Kidney Atlas: Network-based integration of multimodal transcriptomic, proteomic, metabolomic and imaging data in the Kidney Precision Medicine Project. Jens Hansen, Rachel Sealfon, Rajasree Menon, Michael T. Eadon, Blue. Lake, BeckySteck, Dejan Dobi, Samir Parikh, Tara.K. Sidgel, Theodore Alexandrov, AndrewSchroeder, Edgar A. Otto, Christopher R. Anderton, Daria Barwinska, Guanshi Zheng, Michael P. Rose, John P. Shapiro, Dusan Velickovic, Annapurna Pamreddy, SethWinfree, Yongqun He, Ian H. deBoer, JeffreyHodgin, Abhijit Nair, Kumar Sharma, Minnie Sarwal, Kun Zhang, Jonathan Himmelfarb, Zoltan Laszik, Brad Rovin, Pierre C.Dagher, John Cijiang He, Tarek M. El-Achkar, Sanjay Jain, Olga G. Troyanskaya, Matthias Kretzler, Ravi Iyengar, Evren U. Azeloglu, for the Kidney Precision Medicine Project Consortium bioRxiv 2020.07.23.216507; doi:

Nephrology Training: Time to Revisit Integrative Physiology. Bansal, S., Kanakia, R., Sharma, K., Tsai, S., & Prasad, A. (2020). American journal of nephrology, 51(3), 244–248.

Predictive Biomarkers in Nephrology Around the Corner.” Perco, Paul, and Kumar Sharma. Kidney international reportsvol. 5,1 1-3. 2 Nov. 2019, doi:10.1016/j.ekir.2019.10.009

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Francine E. Garrett-Bakelman, Manjula Darshi, Stefan J. Green, Ruben C. Gur, Ling Lin, Brandon R. Macias, Miles J. Mckenna, Cem Meydan, Tejaswini Mishra, Jad Nasrini, Brian D. Piening, Lindsay F. Rizzardi, Kumar Sharma, Jamila H. Siamwala, Lynn Taylor, Martha Hotz Vitaterna, Maryam Afkarian, Ebrahim Afshinnekoo, Sara Ahadi, Aditya Ambati, Maneesh Arya, Daniela Bezdan, Colin M. Callahan, Songjie Chen, Augustine M. K. Choi, George E. Chlipala, Kévin Contrepois, Marisa Covington, Brian E. Crucian, Immaculata De Vivo, David F. Dinges, Douglas J. Ebert, Jason I. Feinberg, Jorge A. Gandara, Kerry A. George, John Goutsias, George S. Grills, Alan R. Hargens, Martina Heer, Ryan P. Hillary, Andrew N. Hoofnagle, Vivian Y. H. Hook, Garrett Jenkinson, Peng Jiang, Ali Keshavarzian, Steven S. Laurie, Brittany Lee-Mcmullen, Sarah B. Lumpkins, Matthew Mackay, Mark G. Maienschein-Cline, Ari M. Melnick, Tyler M. Moore, Kiichi Nakahira, Hemal H. Patel, Robert Pietrzyk, Varsha Rao, Rintaro Saito, Denis N. Salins, Jan M. Schilling, Dorothy D. Sears, Caroline K. Sheridan, Michael B. Stenger, Rakel Tryggvadottir, Alexander E. Urban, Tomas Vaisar, Benjamin Van Espen, Jing Zhang, Michael G. Ziegler, Sara R. Zwart, John B. Charles, Craig E. Kundrot, Graham B. I. Scott, Susan M. Bailey, Mathias Basner, Andrew P. Feinberg, Stuart M. C. Lee, Christopher E. Mason, Emmanuel Mignot, Brinda K. Rana, Scott M. Smith, Michael P. Snyder, Fred W. Turek Science12 Apr 2019

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. Declèves, A. E., Mathew, A. V., Armando, A. M., Han, X., Dennis, E. A., Quehenberger, O., & Sharma, K. (2019). Journal of lipid research, 60(5), 937–952.

Association of Urinary Oxalate Excretion With the Risk of Chronic Kidney Disease Progression. Sushrut S. Waikar, MD, MPH1; Anand Srivastava, MD, MPH2; Ragnar Palsson, MD1; Tariq Shafi, MBBS, MHS3; Chi-yuan Hsu, MD, MSc4; Kumar Sharma, MD5; James P. Lash, MD6; Jing Chen, MD, MMSc, MSc7,8; Jiang He, MD, PhD7,8; John Lieske, MD9; Dawei Xie, PhD10,11; Xiaoming Zhang, MS10,11; Harold I. Feldman, MD, MSCE10,11; Gary C. Curhan, MD, ScD1. JAMA Internal Medicine. March 4, 2019. doi:10.1001/jamainternmed.2018.7980

Effect of renal tubule-specific knockdown of the Na+/H+ exchanger NHE3 in Akita diabetic mice. Akira Onishi, Yiling Fu, Manjula Darshi, Maria Crespo-Masip, Winnie Huang, Panai Song, Rohit Patel, Young Chul Kim, Josselin Nespoux, Brent Freeman, Manoocher Soleimani, Scott Thomson, Kumar Sharma, and Volker Vallon. American Journal of Physiology-Renal Physiology 2019 317:2, F419-F434

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation. Dhanendra Tomar, Fabián Jaña, Zhiwei Dong, William J. Quinn, Pooja Jadiya, Sarah L. Breves, Cassidy C. Daw, Subramanya Srikantan, Santhanam Shanmughapriya, Neeharika Nemani, Edmund Carvalho, Aparna Tripathi, Alison M. Worth, Xueqian Zhang, Roshanak Razmpour, Ajay Seelam, Stephen Rhode, Anuj V. Mehta, Michael Murray, Daniel Slade, Servio H. Ramirez, Prashant Mishra, Glenn S. Gerhard, Jeffrey Caplan, Luke Norton, Kumar Sharma, Sudarsan Rajan, Darius Balciunas, Dayanjan S. Wijesinghe, Rexford S. Ahima, Joseph A. Baur, Muniswamy Madesh. Cell Reports, Volume 26, Issue 13, 2019, Pages 3709-3725.e7, ISSN 2211-1247.

METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease. Theodore Alexandrov, Katja Ovchinnikova, Andrew Palmer, Vitaly Kovalev, ArtemTarasov, Lachlan Stuart, Renat Nigmetzianov, Dominik Fay, Key METASPACE contributors, Mathieu Gaudin, Cristina Gonzalez Lopez, Marina Vetter, John Swales, Mark Bokhart, Mario Kompauer, James McKenzie, Luca Rappez, Dusan Velickovic, Regis Lavigne, Guanshi Zhang, Dinaiz Thinagaran, Elisa Ruhland, Marta Sans, SergioTriana, Denis Abu Sammour, Sarah Aboulmagd, Charlotte Bagger, Nicole Strittmatter, Angelos Rigopoulos, Erin Gemperline, Asta Maria Joensen, Benedikt Geier, ChristineQuiason, Eric Weaver, Mridula Prasad, Benjamin Balluff, Konstantin Nagornov, LingjunLi, Michael Linscheid, Carsten Hopf, Dimitri Heintz, Manuel Liebeke, BernhardSpengler, Berin Boughton, Christian Janfelt, Kumar Sharma, Charles Pineau, Christopher Anderton, Shane Ellis, Michael Becker, József Pánczél, Georges DaViolante, David Muddiman, Richard Goodwin, Livia Eberlin, Zoltan Takats, SheerinShahidi-Latham. bioRxiv 539478; doi:

Increased lipogenesis and impaired β-oxidation predict type 2 diabetic kidney disease progression in American Indians. Afshinnia, F., Nair, V., Lin, J., Rajendiran, T. M., Soni, T., Byun, J., Sharma, K., Fort, P. E., Gardner, T. W., Looker, H. C., Nelson, R. G., Brosius, F. C., Feldman, E. L., Michailidis, G., Kretzler, M., & Pennathur, S. (2019). JCI insight, 4(21), e130317.

Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis. Marius A. Øvrehus, Per Bruheim, Wenjun Ju, Leila R. Zelnick, Knut A. Langlo, Kumar Sharma, Ian H. de Boer, Stein I. Hallan. Kidney International Reports, Volume 4, Issue 2, 2019, Pages 321-333, ISSN 2468-0249.

Molecular Imaging of the Glomerulus via Mesangial Cell Uptake of Radiolabeled Tilmanocept. Zhengtao Qin, Carl K. Hoh, Emilia S. Olson, Amin Haghighat Jahromi, David J. Hall, Christopher V. Barback, Young-Hyun You, Motoko Yanagita, Kumar Sharma and David R. Vera. Journal of Nuclear Medicine September 2019,  60 (9) 1325-1332; DOI:

Global Health Training Opportunities in North American Nephrology Fellowships. Robert Rope, Jeffrey Perl and Shuchi Anand; on behalf of the International Society of Nephrology North American and Caribbean Regional Board. Kidney Int Rep (2019) 4, 904–907;

SAT-LB048 Identification of Pathognomonic Purine Synthesis Biomarkers by Metabolomic Profiling of Youth with Type 2 Diabetes. Jennifer Concepcion, MD, Katherine Chen, BSc, Rin Saito, PhD, Eric Mendez, MD, Jon Gangoiti, MS, Bruce Barshop, MD, PhD, Loki Natarajan, PhD, Kumar Sharma, MD, Jane Kim, MD. Journal of the Endocrine Society, Volume 3, Issue Supplement_1, April-May 2019, SAT–LB048,

Chapter 12 – Role of Mitochondria in the Regulation of Kidney Function and Metabolism in Type 2 Diabetes. Xianlin Han, Yuguang Shi, Maggie Diamond-Stanic, Kumar Sharma. Editor(s): Béatrice Morio, Luc Pénicaud, Michel Rigoulet. Mitochondria in Obesity and Type 2 Diabetes. Academic Press, 2019, Pages 287-300, ISBN 9780128117521.

Management of calciphylaxis in a burn center: A case series and review of the literature.Dado DN , Huang B, Foster DV, Nielsen JS, Gurney JM, Morrow BD, Sharma K, Chung KK, Ainsworth CR. Burns. 2019 Feb;45(1):241-246. PMID: 30322738

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. J Mol Cell Cardiol. 2019 Feb;127:232-245. PMID: 30611795

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema. Kosmider B, Lin CR, Vlasenko L, Marchetti N, Bolla S, Criner GJ, Messier E, Reisdorph N, Powell RL, Madesh M, Kelsen S, Xander N, Correll KA, Mason RJ, Bahmed K. Sci Rep. 2019 Jan 29;9(1):920. PMID: 30696938

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M. ACS Cent Sci. 2019 Jan 23;5(1):153-166. PMID: 30693334

Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury. Nakamura J, Sato Y, Kitai Y, Wajima S, Yamamoto S, Oguchi A, Yamada R, Kaneko K, Kondo M, Uchino E, Tsuchida J, Hirano K, Sharma K, Kohno K, Yanagita M. Kidney Int. 2019 Jan 16. pii: S0085-2538(18)30806-8. PMID: 30661714

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. J Cell Physiol. 2019 Jan 13. PMID: 30637731

Sex-Related Disparities in CKD Progression. Ricardo AC, Yang W, Sha D, Appel LJ, Chen J, Krousel-Wood M, Manoharan A, Steigerwalt S, Wright J, Rahman M, Rosas SE, Saunders M, Sharma K, Daviglus ML, Lash JP; CRIC Investigators. J Am Soc Nephrol. 2019 Jan;30(1):137-146. PMID: 30510134

Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial. de Zeeuw D, Renfurm RW, Bakris G, Rossing P, Perkovic V, Hou FF, Nangaku M, Sharma K, Heerspink HJL, Garcia-Hernandez A, Larsson TE. Lancet Diabetes Endocrinol. 2018 Dec;6(12):925-933. PMID: 30413396

Self-reported Intentional Weight Loss and Risk of Death in Moderate Chronic Kidney Disease in the United States.  Bansal S, Wei G, Boucher RE, Beddhu S.  J Ren Nutr. 2018 Nov;28(6):422-427. PMID: 30077396

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PMID: 30140897

The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation. Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. PMID: 30020827

Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction. Cheung JY, Wang J, Zhang XQ, Song J, Davidyock JM, Prado FJ, Shanmughapriya S, Worth AM, Madesh M, Judenherc-Haouzi A, Haouzi P. Cardiovasc Toxicol. 2018 Oct;18(5):407-419. PMID: 29603116

Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. Myers VD, Tomar D, Madesh M, Wang J, Song J, Zhang XQ, Gupta MK, Tahrir FG, Gordon J, McClung JM, Kontos CD, Khalili K, Cheung JY, Feldman AM. J Cell Physiol. 2018 Sep; 233(9):6319-6326. PMID: 29323723

Molecular regulation of MCU: Implications in physiology and disease. Nemani N, Shanmughapriya S, Madesh M. Cell Calcium. 2018 Sep; 74:86-93. Review. PMID: 29980025

A new drug combination significantly reduces kidney tumor progression in kidney mouse model. Liang S, Cuellar T, Nowacki M, Nayak BK, Dong L, Li B, Sharma K, Habib SL. Oncotarget