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Formed in 2007, the Division of Immunology & Infectious Diseases fully supports the three missions of UT Health San Antonio and the Department of Pediatrics: education, clinical service, and research. We believe that generation and dissemination of new knowledge through the integration of these three missions is the key contribution of academic medicine to society.

The division is actively engaged in the teaching of medical students, pediatric residents, and subspecialty fellows, as well as participating in continuing medical education (CME) activities.

Division faculty provide comprehensive clinical service in the diagnosis and management of children with

  • infectious diseases
  • primary immune deficiency disorders
  • allergic rhinitis, asthma and other types of hypersensitivity
  • rheumatology, including lupus, arthritis and related conditions

Research activities span the spectrum from basic and translational research to clinical research and clinical trials. Please refer to specific programs and faculty web pages for additional details.

Future Plans

Our vision of the future is to provide comprehensive education and training, outstanding clinical care, and to be actively involved in research, in all aspects of immunology, allergy, rheumatology and infectious diseases in children.


Basic and Translational Research


Dr. Brooks laboratory has focused on the interaction of environmental agents with inflammatory reactions in respiratory mucosa as it pertains to mechanisms of oxidative stress in allergy and asthma. We have ongoing investigations in two areas 1) the role of Mycoplasma pneumoniae in asthma and 2) the role of oxidative stress and anti-oxidants on the inflammatory response in asthma.

1) A translational component of this work involves the roles of Mycoplasma pneumoniae in the severity of asthma in collaboration with scientists in the Department of Microbiology and Immunology, Joel Baseman, PhD and Peter Dube, PhD. Our ongoing work in this area involves monitoring patients with asthma and Mycoplasma infection via identification of CARDS Toxin (Community Aquired Respiratory Distress Syndrome) and characterization of the immunological mechanisms (T-cell phenotype) and clinical scores.

2) My lab previously identified non-IgE dependent mechanisms of mast cell activation with pollen from mountain cedar and environmental pollutants, acrolein and SO2, through the generation of reactive oxygen species. We are using animal models of asthma to investigate therapeutic responses to novel strategies targeting the oxidant stress response. Our ongoing studies seek to further define those mechanisms with the goal of developing anti-oxidant therapies for clinical use.


Pediatric residents and fourth-year medical students may choose an elective on Pediatric Infectious Diseases. Electives usually are for 4 weeks, but other lengths of duration may be arranged.

Flexible electives can be arranged for residents wishing to explore options for sub-specialty residency (fellowship) training in Allergy-Immunology, Pediatric Infectious Diseases, or Pediatric Rheumatology.

Students and residents on electives are strongly encouraged to attend weekly Pediatrics Grand Rounds and monthly Pediatrics Research Seminars.

Children’s Immunology Clinic is a training site for the Allergy-Immunology Residency Program administered by the San Antonio Uniformed Services Health Education Command (SAUSHEC).

Course No: PEDI 4016
Course Title: Pediatric Immunology & Infectious Diseases

Kimberly Castillo
Phone: 210-567-5190
Room: 515L Med. Sch. Bldg.
E-mail: castilloka@uthscsa.edu

Faculty Director:
Robert J. Nolan, Jr., MD
Vice chairman for education and training
Location:University Hospital, UHS-Robert B. Green Downtown
Length of Rotation:4 weeks
Period(s) Offered:ALL
Max Students Per Rotation:1
Course Instructor(s): A. Infante, E. Brooks
Course Description:
Students actively participate in all clinical activities of the Division, including outpatient clinics for children with immune deficiency disorders. Emphasis is placed on clinical and laboratory evaluation of infection, immunity, and inflammation, and the management of primary and secondary immune deficiencies, and associated complications.

The scope of infectious diseases typically encountered includes community and hospital acquired infections, including post-surgical infections, infections in cancer patients, and HIV-infected children. Two half-day sessions per week are scheduled in an outpatient clinic for children with AIDS, and one half-day outpatient clinic per week for children with primary immune deficiency disorders. Students also round each weekday with the attending physicians on hospitalized patients. Students spend approximately 16 hours during the rotation in related laboratory experiences covering bacteriology, virology, mycology, flow cytometry, and HLA typing. Scheduled conferences include weekly Case Management Conference and monthly citywide “Bug Club” with other pediatric and internal medicine infectious disease specialists from San Antonio. Students participate in pediatric case conferences by presenting current cases. Students present one 20-minute, clinically-oriented discussion on an infectious disease topic of their choice, prepared with supervision and help from the attending faculty.


Approx. Number of patients per student per week: 15

Approx. Patient encounters: Inpatient: 60%

General Ward: 30%

Intensive Care Unit: 30%

Emergency Room: 0%

Outpatient: 40%

Call Duty Frequency: none

Weekend Duty Frequency: none

Student Evaluation Frequency: at end of rotation

Mandatory Sessions / Conferences:

4 case conferences / 8 laboratory sessions / Student presentation