Publications and Presentations

Nadeau KJ, Arslanian SA, Bacha F, Caprio S, Chao LC, Farrell R, Hughan KS, Rayas M, Tung M, Cross K, El Ghormli L. Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial. Diabetologia. 2025 Mar;68(3):676-87.

Morales DD, Ryu J, Wei C, Hadley JT, Smith MR, Bai J, Lopez-Alvarenga JC, Mummidi S, Duggirala R, Lynch JL, Liu F, Dong LQ. Diet-enhanced LRG1 expression promotes insulin hypersecretion and ER stress in pancreatic beta cells. Diabetologia. 2025 Mar;68(3):615-628. doi: 10.1007/s00125-024-06331-0. Epub 2024 Nov 26. PMID: 39589509.

Haney S, Scherl S, DiMeglio L, Perez-Rossello J, Servaes S, Merchant N; and the COUNCIL ON CHILD ABUSE AND NEGLECT; SECTION ON ORTHOPAEDICS; SECTION ON RADIOLOGY; and SECTION ON ENDOCRINOLOGY(Lynch) ; and the SOCIETY FOR PEDIATRIC RADIOLOGY. Evaluating Young Children With Fractures for Child Abuse: Clinical Report. Pediatrics. 2025 Feb 1;155(2):e2024070074. doi: 10.1542/peds.2024-070074. PMID: 39832712.

Kondetimmanahalli R, Lynch J, Francis G, Gardner H, Pillai R. Pseudohypoparathyroidism type 1A presenting as short stature and congenital hypothyroidism. Endocrinol Diabetes Metab Case Rep. 2025 Jan 27;2025(1):e240097. doi: 10.1530/EDM-24-0097. PMID: 39868553; PMCID: PMC11811821.

Pyle L, Choi YJ, Narongkiatikhun P, Sharma K, Waikar S, Layton A, Tommerdahl KL, de Boer I, Vigers T, Nelson RG, Lynch J, Brosius F 3rd, Saulnier PJ, Goodrich JA, Tryggestad JB, Isganaitis E, Bacha F, Nadeau KJ, van Raalte D, Kretzler M, Heerspink H, Bjornstad P. Proteomic Analysis Uncovers Multi-Protein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus.Clin J Am Soc Nephrol. 2024 Oct 21. doi: 10.2215/CJN.0000000000000559. PMID: 39432369

Koren D, Knutson KL, Burke BK, Drews KL, Bacha F, Katz L, Marcus MD, McKay S, Nadeau K, Mokhlesi B, TODAY Study Group. The association of self-reported sleep and circadian measures with glycemic control and diabetes complications among young adults with type 2 diabetes. American Journal of Physiology-Heart and Circulatory Physiology. 2024 Jun 1;326(6):H1386-95.

JB Tryggestad, MM Kelsey, KL Drews, S Zhou, N Chang, E Escaname, SS Gidding, E Isganaitis, S McKay, R Shah and M Van Name, on behalf of the TODAY Study Group.  Clinical Characteristics of Offspring Born to Parents with Type 2 Diabetes Diagnosed in Youth: Observations from TODAY.  May 24 2024, 11(6), 630; https://doi.org/10.3390/children11060630.

Narongkiatikhun, P., Choi, Y.J., Tommerdahl, K., Sharma, K., Waikar, S., de Boer, I., Cara-Fuentes, G., Lynch, J., Ophascharoensuk, V., Heerspink, H. and Johnson, R., 2024. WCN24-606 Proteiomic Analysis Uncovers new Circulation Proteins Associated with Incident Hypertension over 15 years in Youth with Type 2 Diabetes. Kidney International  Volume 9, Issue 4, Supplement S322-S323 April 2024

El Ghormli L, Wen H, Uschner D, Haymond MW, Hughan KS, Kutney K, Laffel L, Tollefsen SE, Escaname EN, Lynch J, Bjornstad P. Trajectories of eGFR and risk of albuminuria in youth with type 2 diabetes: results from the TODAY cohort study. Pediatric Nephrology. 2023 Dec;38 (12):4137-44.

Mauras, N., Damiano, E.R., El-Khatib, F.H., Marak, M.C., Calhoun, P., Ruedy, K.J., Balliro, C., Li, Z., Beck, R.W., Russell, S.J. and Bionic Pancreas Research Group, June 2023. Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study. Diabetes Technology & Therapeutics, 25(6), pp.437-441.

BJORNSTAD P, VIGERS TB, DE BOER IA, EL GHORMLI LA, HEERSPINK HL, LAFFEL LM, RYDER JR, SHAH AS, LYNCH JL, GUBITOSI-KLUG RO, DREWS K. 1096-P: Plasma Metabolites Predict Loss of Glycemic Control in Youth with Type 2 Diabetes (T2D). Diabetes. 2023 Jun 20;72(Supplement_1).

Castellanos LE, Russell SJ, Damiano ER, Beck RW, Shah VN, Bailey R, Calhoun P, Bird K, Mauras N; Bionic Pancreas Research Group. The Insulin-Only Bionic Pancreas Improves Glycemic Control in Non-Hispanic White and Minority Adults and Children With Type 1 Diabetes. Diabetes Care. 2023 Mar 31:dc221478. doi: 10.2337/dc22-1478. PMID: 37000680.

Mauras N, Damiano ER, El-Khatib FH, Marak MC, Calhoun P, Ruedy KJ, Balliro C, Li Z, Beck RW, Russell SJ. Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study. Diabetes Technol Ther. 2023 Mar 22. doi: 10.1089/dia.2022.0461. Epub ahead of print. PMID: 36877259.

Laffel LM, Danne T, Klingensmith GJ, Tamborlane WV, Willi S, Zeitler P, Neubacher D, Marquard J; DINAMO Study Group. Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial. Lancet Diabetes Endocrinol. 2023 Mar;11(3):169-181. doi: 10.1016/S2213-8587(22)00387-4. Epub 2023 Feb 1. PMID: 36738751.

Rose SR, Wassner AJ, Wintergerst KA, Yayah-Jones NH, Hopkin RJ, Chuang J, Smith JR, Abell K, LaFranchi SH; SECTION ON ENDOCRINOLOGY EXECUTIVE COMMITTEE; COUNCIL ON GENETICS EXECUTIVE COMMITTEE. Congenital Hypothyroidism: Screening and Management. Pediatrics. 2023 Jan 1;151(1):e2022060419. doi: 10.1542/peds.2022-060419. PMID: 36827523.

TODAY Study Group, and Bjornstad Petter El ghormli Laure Hughan Kara S. Laffel Lori M. Nadeau Kristen J. Rayas Maria Tesfaldet Bereket Tollefsen Sherida E. Willi Steven M. Lynch Jane. “Effects of metabolic factors, race-ethnicity, and sex on the development of nephropathy in adolescents and young adults with type 2 diabetes: results from the TODAY study.” Diabetes Care 45.5 (2022): 1056-1064.

Bionic Pancreas Research Group, Russell SJ, Beck RW, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Calhoun P, Wadwa RP, Buckingham B, Zhou K, Daniels M, Raskin P, White PC, Lynch J, Pettus J, Hirsch IB, Goland R, Buse JB, Kruger D, Mauras N, Muir A, McGill JB, Cogen F, Weissberg-Benchell J, Sherwood JS, Castellanos LE, Hillard MA, Tuffaha M, Putman MS, Sands MY, Forlenza G, Slover R, Messer LH, Cobry E, Shah VN, Polsky S, Lal R, Ekhlaspour L, Hughes MS, Basina M, Hatipoglu B, Olansky L, Bhangoo A, Forghani N, Kashmiri H, Sutton F, Choudhary A, Penn J, Jafri R, Rayas M, Escaname E, Kerr C, Favela-Prezas R, Boeder S, Trikudanathan S, Williams KM, Leibel N, Kirkman MS, Bergamo K, Klein KR, Dostou JM, Machineni S, Young LA, Diner JC, Bhan A, Jones JK, Benson M, Bird K, Englert K, Permuy J, Cossen K, Felner E, Salam M, Silverstein JM, Adamson S, Cedeno A, Meighan S, Dauber A. Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes. N Engl J Med. 2022 Sep 29;387(13):1161-1172. doi: 10.1056/NEJMoa2205225. PMID: 36170500.

Bionic Pancreas Research Group Messer LH, Buckingham BA, Cogen F, Daniels M, Forlenza G, Jafri RZ, Mauras N, Muir A, Wadwa RP, White PC, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Marak MC, Calhoun P, Beck RW. Positive Impact of the Bionic Pancreas on Diabetes Control in Youth 6-17 Years Old with Type 1 Diabetes: A Multicenter Randomized Trial. Diabetes Technol Ther. 2022 Oct;24(10):712-725. doi: 10.1089/dia.2022.0201.pub. PMID: 36173237; PMCID: PMC9529304.

Bionic Pancreas Research Group, Jane Lynch, Lauren G. Kanapka, Steven J. Russell, Edward R. Damiano, Firas H. El-Khatib, Katrina J. Ruedy, Courtney Balliro, Peter Calhoun, and Roy W. Beck. “The insulin-only bionic pancreas pivotal trial extension study: a multi-center single-arm evaluation of the insulin-only configuration of the bionic pancreas in adults and youth with type 1 diabetes.” Diabetes technology & therapeutics 24, no. 10 (2022): 726-736.

Lynch J, Kanapka LG, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Calhoun P, Beck RW. Bionic Pancreas Research Group The Insulin-Only Bionic Pancreas Pivotal Trial Extension Study: A Multi-Center Single-Arm Evaluation of the Insulin-Only Configuration of the Bionic Pancreas in Adults and Youth with Type 1 Diabetes. Diabetes Technol Ther. 2022 Oct;24(10):726-736. doi: 10.1089/dia.2022.0341. PMID: 36173238; PMCID: PMC9529297.

TODAY Study Group. Longitudinal Association of Depressive Symptoms, Binge Eating, and Quality of Life With Cardiovascular Risk Factors in Young Adults With Youth-Onset Type 2 Diabetes: The TODAY2 Study. Diabetes Care. 2022 Mar 15:dc211995. doi: 10.2337/dc21-1995. PMID: 35290434.

TODAY Study Group, Shah RD, Braffett BH, Tryggestad JB, Hughan KS, Dhaliwal R, Nadeau KJ, Levitt Katz LE, Gidding SS. Cardiovascular risk factor progression in adolescents and young adults with youth-onset type 2 diabetes. J Diabetes Complications. 2022 Mar;36(3):108123. doi: 10.1016/j.jdiacomp.2021.108123. Epub 2022 Jan 3. PMID: 35123868; PMCID: PMC8903081

Shah AS, Gidding SS, El Ghormli L, Tryggestad JB, Nadeau KJ, Bacha F, Levitt Katz LE, Willi SM, Lima J, Urbina EM; TODAY Study Group. Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study. J Am Soc Echocardiogr. 2022 Feb 8:S0894-7317(22)00057-8. doi: 10.1016/j.echo.2022.02.001. Epub ahead of print. PMID: 35149207.

He S, Ryu J, Liu J, Luo H, Lv Y, Langlais PR, Wen J, Dong F, Sun Z, Xia W, Lynch JL, Duggirala R, Nicholson BJ, Zang M, Shi Y, Zhang F, Liu F, Bai J, Dong LQ. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance. J Clin Invest. 2021 Dec 15;131(24):e148545. doi: 10.1172/JCI148545. PMID: 34730111; PMCID: PMC8670837.

Abstracts Presented

Desirae Morales, D, Cong W, Jiyoon, R, Maia Rose, S, Lynch J.  LRG1 Mediates Diet-Induced Adipose Tissue Dysfunction in Adolescent Mice The Obesity Society Nov 3-6 2024 San Antonio

Trends of Diabetes in Youth (TrenDY) during COVID-19 across the United States. #2024-LB-5542-Diabetes, American Diabetes Association’s 84th Scientific Sessions, June 21-24, 2024 in Orlando, Florida 1947-LB

Diet-Induced Upregulation of LRG1 Contributes to Renal Lipotoxicity and Damage in Chronic Kidney Disease Cong Wei1, Desirae Morales1, Jiyoon Ryu1, Jason Hadley1, Juli Bai1, Ravindranath Duggirala2, Jane L. Lynch3, Li Xiao4, Lily Q. Dong1* ADA 0307 CW 2024

Obesity Society Nov 3-6  2024 Abstract: Impact of Early Life Exposures to Organic Chemicals on Cardiometabolic Risk in Hispanic Children: A Pilot Tooth Study Farook VS*1, Akhtar F*2, Arya R2, Yau A3, Mummidi S2, Resendez RG2, Pinki Anand2, Alvaro Diaz-Badillo2, Fowler SP4, Lynch JL5, Vijay Golla2, Lehman DM2, Hale DE6, DeFronzo RA4, Blangero J1, Camann DE3, Duggirala R2, Challa S7

Obesity Society Nov 3-6  2024 Abstract: dentification of Potential Functional Variants Influencing the LRG1 Levels in Mexican American Children Anand P1, Reyna A2, Almeida M3, Morales L3, Resendez RG1, Fowler SP4, Ezeilo JA1, Akhtar F1, Diaz-Badillo A1, Kumar S3, Curran JE3, Lehman DM1, Hale DE5, Lopez-Alvarenga JC6, Golla V1, Arya R1, Lynch JL7, DeFronzo RA4, Blangero J3, Mummidi S1, Dong LQ8, Duggirala R1

Cong Wei1, Desirae Morales1, Jiyoon Ryu1, Jason Hadley1, Juli Bai1, Maia Smith1, Ravindranath Duggirala2, Jane L. Lynch3, Chen Wei4, Li Xiao5, Lily Q. Dong1* Obesity Society Nov 3-6  2024 Abstract: Diet-Induced Upregulation of LRG1 Contributes to Renal Lipotoxicity in Chronic Kidney Disease.

3-Year-Old Male with Acute Lymphoblastic Leukemia and Severe Persistent Hypoglycemia.  UT Health San Antonio 2024 Research Symposium. May 17, 2024. M. Khan, J. Lynch, A. Grimes.

Impact of Early Life Exposures to Organic Chemicals on Cardiometabolic Risk in Hispanic Children: A Pilot Tooth Study Farook VS, Akhtar F, Arya R, Yau A, Mummidi S, Resendez RG, Pinki Anand, Alvaro Diaz-Badillo, Fowler SP, Lynch JL, Vijay Golla, Lehman DM, Hale DE, DeFronzo RA, Blangero J, Camann DE, Duggirala R, Challa S. Obesity Society, Nov 3-6, 2024

LRG1 Mediates Diet-Induced Adipose Tissue Dysfunction in Adolescent Mice.  Desirae Morales, MS; Jiyoon Ryu, PhD, Cong Wei, BS; Ravindranath Duggirala, PhD; Jane L. Lynch, MD and Lily Q, Dong, PhD.  Obesity Society.  Nov. 3-6, 2024

Identification of Potential Functional Variants Influencing the LRG1 Levels in Mexican American Children.  Anand P, Reyna A, Almeida M, Morales L, Resendez RG, Fowler SP, Ezeilo JA, Akhtar F, Diaz-Badillo A, Kumar S, Curran JE, Lehman DM, Hale DE, Lopez-Alvarenga JC, Golla V1, Arya R, Lynch JL, DeFronzo RA, Blangero J, Mummidi S, Dong LQ, Duggirala R.  Obesity Society, Nov. 3-6, 2024.

Diet-Induced Upregulation of LRG1 Contributes to Renal Lipotoxicity and Damage in Chronic Kidney Disease Cong Wei1, Desirae Morales, Jiyoon Ryu, Jason Hadley, Juli Bai, Ravindranath Duggirala, Jane L. Lynch, Li Xiao, Lily Q. Dong  ADA 0307 CW JUN 21-24, 2024

LRG1 Mediates Diet-Induced Adipose Tissue Dysfunction & Fatty Liver in Adolescent Mice. Desirae Morales, MS; Jiyoon Ryu, PhD; Cong Wei, BS; Ravindranath Duggirala, PhD; Jane L. Lynch, MD and Lily Q. Dong, PhD. PESTOLA 2024, San Antonio, TX  April 5-7, 2024.

LRG1 Deficiency in Adolescent Mice Confers Protection Against Diet-Induced Kidney Damage. Cong Wei, BS; Desirae Morales, MS; Jane L. Lynch, MD; Ravindranath Duggirala, PhD; and Lily Q. Dong, PhD.  PESTOLA 2024, San Antonio, TX. April 5-7, 2024

Incidence of New Onset Pediatric Type 1 and Type 2 Diabetes in San Antonio from 2019 to 2021. M. Khan, DO; A. Vosberg; J. Guerra, MPH; M. Zozus, Ph.D; M. Rayas, MD; Jane Lynch, MD; Golareh Agha, Ph.D  PESTOLA April 6, 2024

X-Adrenoleukodystrophy. Who Is Taking Care Of The Family? F. Reyes San Martin MD., J. Lynch MD. PESTOLA Poster,  April 6, 2024

Characteristics of New Onset Pediatric Type 1 and 2 Diabetes in San Antonio from 2019 to 2021. Vosberg A, Khan M, Lynch,J Guerra G, Golareh A. Southern Society for Pediatric Research Feb 22, 2024, Oral Abstract Presentation # 197: New Orleans, Louisiana

Bjornstad P, Vigers TB, De Boer I, El Ghormli L, Heerspink HL, Laffel LM, Ryder JR, Shah AS, Lynch JL, Gubitosi-Klug, R, Drews K, Tommerdahl, KL, Tryggestad JB, Isganaitis EM, Bacha F, Pyle L, Sharma K. P. Pediatrics -Obesity and Type 2 Diabetes JUN 2023; 72(Supplement_1):1096-P ;  DOI:10.2337/db23-1096-P

Morales, Desirae & RYU, JIYOON & Lynch, Jane & Duggirala, Ravindranath & Dong, Lily. (2022). 995-P: LRG1 Mediates Diet-Induced Hyperinsulinemia by Enhancing Glucose-Stimulated Insulin Secretion. Diabetes. 71. 10.2337/db22-995-P.

Grant

Baptist Health Foundation Grant

Susan R. Rose, Ari J. Wassner, Kupper A. Wintergerst, Nana-Hawa Yayah-Jones, Robert J. Hopkin, Janet Chuang, Jessica R. Smith, Katherine Abell, Stephen H. LaFranchi, SECTION ON ENDOCRINOLOGY EXECUTIVE COMMITTEE, COUNCIL ON GENETICS EXECUTIVE COMMITTEE; Congenital Hypothyroidism: Screening and Management. Pediatrics January 2023; 151 (1): e2022060420. 10.1542/peds.2022-060420 PMID: 36827523

Castellanos LE, Russell SJ, Damiano ER, Beck RW, Shah VN, Bailey R, Calhoun P, Bird K, Mauras N; Bionic Pancreas Research Group. The Insulin-Only Bionic Pancreas Improves Glycemic Control in Non-Hispanic White and Minority Adults and Children With Type 1 Diabetes. Diabetes Care. 2023 Mar 31:dc221478. doi: 10.2337/dc22-1478. Epub ahead of print. PMID: 37000680.

Mauras N, Damiano ER, El-Khatib FH, Marak MC, Calhoun P, Ruedy KJ, Balliro C, Li Z, Beck RW, Russell SJ. Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study. Diabetes Technol Ther. 2023 Mar 22. doi: 10.1089/dia.2022.0461. Epub ahead of print. PMID: 36877259.

Francis GL. Macro–Thyrotropin and Other Disorders in the Differential Diagnosis of Congenital Hypothyroidism. Clinical Thyroidology 2023 Feb; 132(11) 142–146. Published Online:11 April 2023.

J. Carey; J. Cody, J. Mehl; J. Gelfond. Causes of death and associated factors in patients with trisomy 18 syndrome and long-term survival. Volume 1, Issue 1, Supplement, 100167, 2023. Genetics of Medicine Open. https://doi.org/10.1016/j.gimo.2023.100167

Jill Weissberg-Benchell, PhD¹; Anthony T. Vesco, PhD¹; Jenna Shapiro, PhD¹; Peter Calhoun, PhD²; Edward R. Damiano, PhD^3,4; Steven J. Russell, MD, PhD⁴; Zoey Li, MS²; Firas H. El-Khatib, PhD⁴; Katrina J. Ruedy, MSPH²; Courtney A. Balliro, RN⁴; Roy W. Beck, MD, PhD²; and the Bionic Pancreas Research Group*, Psychosocial Impact of the Insulin-Only iLet Bionic Pancreas for Adults, Youth, and Caregivers of Youth with Type 1 Diabetes, (In press)

Lynch J, Hughan K, Kutney K, Tollefsen S;Uschner D, Laffel, L, Haymond, M, Escaname, E, Wen W. Trajectories of eGFR and risk of albuminuria in youth with T2D: results from the TODAY cohort study.  Pediatric Nephrology (In press)

Francis GL. Thyroid Function Abnormalities in Childhood Cancer Survivors. Clinical Thyroidology 2023 Apr (in press)

Messer LH, Buckingham BA, Cogen F, Daniels M, Forlenza G, Jafri RZ, Mauras N, Muir A, Wadwa RP, White PC, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Marak MC, Calhoun P, Beck RW. Positive Impact of the Bionic Pancreas on Diabetes Control in Youth 6-17 Years Old with Type 1 Diabetes: A Multicenter Randomized Trial. Diabetes Technol Ther. 2022 Oct;24(10):712-725. doi: 10.1089/dia.2022.0201.pub. PMID: 36173237; PMCID: PMC9529304.

Lynch J, Kanapka LG, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Calhoun P, Beck RW. The Insulin-Only Bionic Pancreas Pivotal Trial Extension Study: A Multi-Center Single-Arm Evaluation of the Insulin-Only Configuration of the Bionic Pancreas in Adults and Youth with Type 1 Diabetes. Diabetes Technol Ther. 2022 Oct;24(10):726-736. doi: 10.1089/dia.2022.0341. PMID: 36173238; PMCID: PMC9529297.

Beck RW, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Li Z, Calhoun P. A Multicenter Randomized Trial Evaluating Fast-Acting Insulin As part in the Bionic Pancreas in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2022 Oct;24(10):681-696. doi: 10.1089/dia.2022.0167. PMID: 36173235; PMCID: PMC9529301.

Bionic Pancreas Research Group, Russell SJ, Beck RW, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Calhoun P, Wadwa RP, Buckingham B, Zhou K, Daniels M, Raskin P, White PC, Lynch J, Pettus J, Hirsch IB, Goland R, Buse JB, Kruger D, Mauras N, Muir A, McGill JB, Cogen F, Weissberg-Benchell J, Sherwood JS, Castellanos LE, Hillard MA, Tuffaha M, Putman MS, Sands MY, Forlenza G, Slover R, Messer LH, Cobry E, Shah VN, Polsky S, Lal R, Ekhlaspour L, Hughes MS, Basina M, Hatipoglu B, Olansky L, Bhangoo A, Forghani N, Kashmiri H, Sutton F, Choudhary A, Penn J, Jafri R, Rayas M, Escaname E, Kerr C, Favela-Prezas R, Boeder S, Trikudanathan S, Williams KM, Leibel N, Kirkman MS, Bergamo K, Klein KR, Dostou JM, Machineni S, Young LA, Diner JC, Bhan A, Jones JK, Benson M, Bird K, Englert K, Permuy J, Cossen K, Felner E, Salam M, Silverstein JM, Adamson S, Cedeno A, Meighan S, Dauber A. Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes. N Engl J Med. 2022 Sep 29;387(13):1161-1172. doi: 10.1056/NEJMoa2205225. PMID: 36170500.

Gandica R, Weinstock RS, Gunaratne M, Arslanian S, Doherty L, Geffner ME, Laffel L, Higgins J; TODAY Study Group. Long-Term Retention of Young Adult Study Participants with Youth-Onset Type 2 Diabetes: Results from the TODAY2 Study. Horm Res Paediatr. 2023;96(3):325-331. doi: 10.1159/000528205. Epub 2022 Nov 21. PMID: 36412631.

TODAY Study Group. Long-term Outcomes Among Young Adults With Type 2 Diabetes Based on Durability of Glycemic Control: Results From the TODAY Cohort Study. Diabetes Care. 2022 Nov 1;45(11):2689-2697. doi: 10.2337/dc22-0784. PMID: 36190810; PMCID: PMC9679266.

Levitsky LL, Drews KL, Haymond M, Glubitosi-Klug RA, Levitt Katz LE, Mititelu M, Tamborlane W, Tryggestad JB, Weinstock RS; TODAY Study Group. The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study. J Diabetes Complications. 2022 Nov;36(11):108259. doi: 10.1016/j.jdiacomp.2022.108259. Epub 2022 Jul 19. PMID: 36150365.

Mittileu M, Uschner D, Doherty L, Bjornstad P, Domalpally A, Drews KL, Gubitosi-Klug R, Levitsky LL, Pak JW, White NJ, Blodi BA, TODAY Study Group. Retinal Thickness and Morphology Changes on OCT in Youth with Type 2 Diabetes.  Findings from the TODAY Study.  Ophthalmol Sci. 2022 Jun 28;2(4):100191. doi: 10.1016/j.xops.2022.100191. eCollection 2022 Dec. PMID: 36531589.

Luisa Rodriguez, MD, MS1, Catherine Dinauer, MD2, Gary Francis, MD, PhD3. Treatment of Hypothyroidism in Infants, Children and Adolescents. Trends in Endocrinology and Metabolism, VOLUME 33, ISSUE 7, P522-532, JULY 01, 2022. PMID: 35537910

Catherine E. Kerr, MD1; Jorge Velez, MD2; Jay Ferrell, MD3; Mio Kitano, MD4; Dr. Wouter Koek, PhD5; Patricia Dahia, MD, PhD6; and Gary Francis, MD, PhD1. Thyroid Nodules of Indeterminate Cytology in Hispanic/Latinx Patients. Head and Neck, 2022 Aug;44(8):1842-1848. PMID: 35583054.

Francis, GL. Review of: Bardugo A, Derazne E, Zucker I, Bendor C, Puris G, Lutski M, Pinhas-Hamiel O, Cukierman-Yaffe T, MosenzonO\ O, Schechter M, Tzur D, Afek A, Tirosh A, Gerstein H, Raz I, and Twig G 2021. Adolescent Thyroid Disorders and Risk for Type 2 Diabetes in Young Adult. J Clin Endocrinol Metab 106:e3426-e3435 Adolescent Thyroid Disease and Risk for Adult Type 2 Diabetes. Clinical Thyroidology 34 (1) 6-9, 2022. PMID: 34050759

Francis, GL. What’s the Likelihood of Post-Lobectomy Hypothyroidism in Children? Clinical Thyroidology 34(3) 100-102, 2022. https://doi.org/10.1089/ct.2022;34.100-102. PMID: 19789012

Francis, GL. The Future of Molecular Profiling for the Treatment of Pediatric Thyroid Cancer. Review of: NTRK and RET fusion–directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake. J Clin Invest. 131(18):e144847  https://doi.org/10.1172/JCI144847. Clinical Thyroidology, 34(4)2022:157-160. PMID: 34237031

Francis GL. Screening for Neonatal Hyperthyroidism. A review of: Banigé M, Kariyawasam D, Gauthereau V, Luton D, Polak M 2022 Neonatal Screening for Hyperthyroidism Proof of Concept. J Clin Endocrinol Metab Mar 24;107(4):e1374-e1381. doi: 10.1210/clinem/dgab890. Clinical Thyroidology 34:282-285, 2022. PMID: 34894265

Francis GL. Trends in Lobectomy for Pediatric Thyroid Cancer. A review of: Eli Stein BS, Mehul V. Raval MD, MS, Inbal Hazkani MD, Audra Reiter MD, MPH, Jami L. Josefson MD, Jill H. Samis MD, and Jeffrey C. Rastatter MD, MS. The 2015 American Thyroid Association guidelines and trends in hemithyroidectomy utilization for pediatric thyroid cancer. Head & Neck. 2022;44:1833–1841. Clinical Thyroidology 34(8) 347-350, 2022.

Francis GL. Trends in Pediatric and Adult Iodine Status in the United States. Review of: Zhang K, Cheng J, Yu J, Chen Y, Shi X, Zhu C, Lu Y, Wang N, Han B 2022 Trends in iodine status among U.S. children and adults: A cross-sectional analysis of National Health and Nutrition Examination Survey data from 2001–2004 to 2017–2020. Thyroid 32:962–971. PMID: 35822552. Clinical Thyroidology 34(11) 2022.

Francis GL. Maternal Thyroid Autoimmunity Affects the Emotional and Behavioral Development of the Offspring. A Review of: Teng Y, Li P, Yang M, Han Y, Yan S, Xu Y, Tao F, Huang K 2022 Sex-specific effect of thyroid peroxidase antibody and thyroglobulin antibody exposure during pregnancy on preschoolers’ emotional and behavioral development: A birth cohort study. Thyroid 32:1229–1242. PMID: 35920111. Clinical Thyroidology 34(12):521-525, 2022.

Francis GL. Inadvertent Parathyroid Gland Removal During Thyroid Surgery in Children. A review of: Ziai H, Dixon P, Berman G, Campisi P, Wasserman JD. 2002 Incidental Parathyroidectomy Among Pediatric Patients Undergoing Thyroid Surgery. Laryngoscope. 2022 Nov;132(11):2262-2269. doi: 10.1002/lary.30056. Epub 2022 Feb 22. PMID: 35191038 Clinical Thyroidology February 2023. PMID: 35191038

Postintervention Effects of Varying Treatment Arms on Glycemic Failure and β-Cell Function in the TODAY Trial. Diabetes Care. 2021 Jan;44(1):75-80. doi: 10.2337/dc20-0622. Epub 2020 Nov 10. PMID: 33290248

Castellanos LE, Balliro CA, Sherwood JS, Jafri R, Hillard MA, Greaux E, Selagamsetty R, Zheng H, El-Khatib FH, Damiano ER, Russell SJ. Performance of the Insulin-Only iLet Bionic Pancreas and the Bihormonal iLet Using Dasiglucagon in Adults With Type 1 Diabetes in a Home-Use Setting. Diabetes Care. 2021 Apr 27:dc201086. doi: 10.2337/dc20-1086. Epub ahead of print. PMID: 33906916.

TODAY Study Group; Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler P. Long-Term Complications in Youth-Onset Type 2 Diabetes. N Engl J Med. 2021 Jul 29;385(5):416-426. doi: 10.1056/NEJMoa2100165. PMID: 34320286; PMCID: PMC8697255.

TODAY Study Group. Effects of Metabolic Factors, Race-Ethnicity, and Sex on the Development of Nephropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study. Diabetes Care. 2021 Sep 16;45(5):1056–64. doi: 10.2337/dc21-1085. Epub ahead of print. PMID: 34531309; PMCID: PMC9174961.

He S, Ryu J, Liu J, Luo H, Lv Y, Langlais PR, Wen J, Dong F, Sun Z, Xia W, Lynch JL, Duggirala R, Nicholson BJ, Zang M, Shi Y, Zhang F, Liu F, Bai J, Dong LQ. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance. J Clin Invest. 2021 Dec 15;131(24):e148545. doi: 10.1172/JCI148545. PMID: 34730111; PMCID: PMC8670837.

Sherwood JS, Jafri RZ, Balliro CA, Zheng H, FH El-Khatib, ER Damiano, SJ Russell, MS Putman. Automated glycemic control with the bionic pancreas in cystic fibrosis-related diabetes: A pilot study. J Cyst Fibros 2020; Jan;19(1):159-161. doi: 10.1016/j.jcf.2019.08.002. Epub 2019 Aug 13. PMID: 31420176

Bjornstad P, Hughan K, Kelsey MM, Shah AS, Lynch J, Nehus E, Mitsnefes M, Jenkins T, Xu P, Xie C, Inge T, Nadeau K. Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes. Diabetes Care. 2020 Jan ;43(1):187-195. doi: 10.2337/dc19-0708 Epub 2019 Nov 4. PMID: 31685489 PMCID: PMC6925577

Cody JD. Molecular biology of abnormal gene dosage: lessons from chromosome 18 Trends in Genetics. 2020 Jan PMID: 32660784

Jalaludin MY, Barrientos-Pérez M, Hafez M, Lynch J, Shehadeh N, Turan S, Weghuber D. Recommendations for improving clinical trial design to facilitate the study of youth-onset type 2 diabetes. Clin Trials 2020 Feb;17(1):87-98 doi: 10.1177/1740774519870190. Epub 2019 Aug 26. PMID: 31450961

HE Rizzo, EN Escaname, NB Alana, E Lavender, J Gelfond, R Fernandez, MA Hibbs, JM King, NR Carr, CL Blanco. Maternal Diabetes and obesity influence the fetal epigenome in a largely Hispanic population. Clinical Epigenetics 2020 Feb 19;12(1):34. Doi:10.1186/s13148-020-0824-9. PMID: 32075680

Shah R, McKay SV, Levitt Katz LE, El Ghormli L, Anderson BJ, Casey TL, Higgins L, Izquierdo R, Wauters AD, Chang N; TODAY Study Group.(J Lynch, E Escaname, M Rayas) Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication. J Pediatr Endocrinol Metab. 2020 Feb 25;33(2):191-198. doi: 10.1515/jpem-2019-0315. PMID: 31809265.

Catherine Kerr MD, Gary Francis MD PhD. Thyroid Nodules in Children and Adolescents. Journal of Radiology and Imaging Science. J Radiol & Imaging Sci. March 2020;1(1):1-5.

Kaar JL, Schmiege SJ, Drews K, Higgins J, Walders-Abramson N, Isganaitis E, Willi SM, Marcus MD, Zeitler PS, Kelsey MM. Evaluation of the longitudinal change in health behavior profiles across treatment groups in the TODAY clinical trial. (J Lynch, E Escaname, M Rayas) Pediatr Diabetes. 2020 Mar;21(2):224-232. doi: 10.1111/pedi.12976 PMID: 31886931.

MA Van Name, P Cheng, RL Gal, C Kollman, J Lynch, B Nelson, WV Tamborlane, & Pediatric Diabetes Consortium [J Lynch, C Orsi, M Rayas, E Escaname, R Barajas]. Children and adolescents with type 1 and type 2 diabetes mellitus in the Pediatric Diabetes Consortium Registries: comparing clinical characteristics and glycaemic control. Diabetic Medicine 2020 May;37(5), 863-867. Doi:10.1111/dme.14233 Epub 2020 Feb 5. PMID: 31943374

Phillips WT, Kukkar V, Francis GL, Gorzell BC, Cooper AW, Metter DF, LancasterJL. FASpecT/CT, A New SPECT/CT Acquisition With Higher Sensitivity and Efficiency in Radioiodine Thyroid Cancer Imaging. Clin Nucl Med. 2020 May;45(5):356-364. PMID: 32149813.

Sengwee Toh, Sheryl L Rifas-Shiman, Pi-I D Lin, L Charles Bailey, Christopher B Forrest, Casie E Horgan, Douglas Lunsford, Erick Moyneur, Jessica L Sturtevant, Jessica G Young, Jason P Block, PCORnet Antibiotics and Childhood Growth Study Group: Maria Rayas. Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study. Pediatr Res 2020 May; 87(6):1086-1092. PMID: 31578038

Jafri R, Balliro C, El-Khatib F, et al. A Three-way Accuracy Comparison of the Dexcom G5, Abbott Freestyle Libre Pro, and Senseonics Eversense CGM Devices in an Home-Use Study of Subjects with Type 1 Diabetes. Diabetes Technol Ther 2020 May 26. doi: 10.1089/dia.2019.0449 Online ahead of print PMID: 32453604

Arslanian S, El Ghormli L, Haymond MH, Chan CL, Chernausek SD, Gandica RG, Gubitosi-Klug R, Levitsky LL, Siska M, Willi SM; TODAY Study Group. (J Lynch, E Escaname, M Rayas) Beta cell function and insulin sensitivity in obese youth with maturity onset diabetes of youth mutations vs type 2 diabetes in TODAY: Longitudinal observations and glycemic failure. Pediatr Diabetes. 2020 Jun;21(4):575-585. doi: 10.1111/pedi.12998. Epub 2020 Mar 3. PMID: 32064729

Kumar, S., Lteif, A., Lynch, J., Aye, T., & Ashraf, A. (2020, June). Perspectives of Pediatric Endocrinologists on Career Choice and Strategies to Stimulate Interest in Pediatric Endocrinology Subspecialty Training. In HORMONE RESEARCH IN PAEDIATRICS (Vol. 93, No. SUPPL 1, pp. 141-142). PMID: 34132198

Allen N, Desai N, Song C, Yu J, Prasad U & Francis G. Clinical features may help to identify children and adolescents with greatest risk for thyroid nodules. J Endocrinol Invest July 2020. 43(7):925-934. PMID: 31927747

Allen N, N Desai, C Song, J Yu, U Prasad, G Francis Clinical Features May Help to Identify Children and Adolescents With Greatest Risk for Thyroid Nodules. J Endocrinol 2020 Jul;43(7):925-934. Doi: 10.1007/s40618-019-01176-6. Epub 2020 Jan 11. PMID: 31927747

Lynch JL, Barrientos-Pérez M, Hafez M, Jalaludin MY, Kovarenko M, Rao PV, Weghuber D. Country-Specific Prevalence and Incidence of Youth-Onset Type 2 Diabetes: A Narrative Literature Review. Ann Nutr Metab. 2020;76(5):289-296. doi: 10.1159/000510499. Epub 2020 Sep 25. PMID: 32980841.

Tryggestad JB, Shah RD, Braffett BH, Bacha F, Gidding SS, Gubitosi-Klug RA, Shah AS, Urbina EM, Levitt Katz LE; TODAY Study Group. Circulating adhesion molecules and associations with HbA1c, hypertension, nephropathy, and retinopathy in the Treatment Options for type 2 Diabetes in Adolescent and Youth study. Pediatr Diabetes. 2020 Sep;21(6):923-931. doi: 10.1111/pedi.13062. Epub 2020 Jul 2. PMID: 32501612

Endocrine Conditions in Pediatrics. Ambreen Sonawalla, Rabab Jafri: Type 1 Diabetes. Published September 2020. pp 307-311 i. Ilet Function in Youth with Cystic Fibrosis with and without Liver Disease

Lopez-Alvarenga JC, Chittoor G, Paul SFD, Puppala S, Farook VS, Fowler SP, Resendez RG, Hernandez-Ruiz J, Diaz-Badillo A, Salazar D, Garza DD, Lehman DM, Mummidi S, Arya R, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R. Acanthosis nigricans as a composite marker of cardiometabolic risk and its complex association with obesity and insulin resistance in Mexican American children. PLoS One. 2020 Oct 15;15(10):e0240467. doi: 10.1371/journal.pone.0240467. PMID: 33057385

Health Care Coverage and Glycemic Control in Young Adults With Youth-Onset Type 2 Diabetes: Results From the TODAY2 Study. Diabetes Care. 2020 Oct;43(10):2469-2477. doi: 10.2337/dc20-0760. Epub 2020 Aug 10. PMID: 32778555

T Quattrin, MJ Haller, AK Steck, EI Felner, Y Li, Y Xia, JH Leu, R Zoka, JA Hedrick, MR Rigby, F Vercruysse, T1GER Study Investigators Collaborators. L Akright, S Aronoff, B Bode, L Chuck, L DiMeglio, E Felner, D Flynn, J Gaglia, S Gitelman, M Gottschalk, C Greenbaum, M Haller, K Herold, D Hsia, G Kletter, S Leichter, W Miers, L Philipson, G Prakasam, M Rayas, T Quattrin, B Reiner, A Steck, M Thompson, D Weiss, S Willi, K Wintergerst. Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes. N Engl J Med 2020 Nov 383(21):2007-2017. PMID: 33207093

Sandhu S, Orsi C, Francis GL, Wang Z, Fernandez R, Alkhouri N. Shear wave elastography reveals a high prevalence of liver fibrosis in overweight or obese Hispanic youth. J Ultrason. 2020 Nov;20(82):e162-e168. doi: 10.15557/JoU.2020.0027. PMID: 33365151

Srinivas, Mummidi, Vidya S. Farook, Reddivari Lavanya, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, Sharon P. Fowler, Roy G. Resendez et al. “Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children.” Scientific Reports (Nature Publisher Group) 11, no. 1. PMID: 33441626

Christison- Lagay ER, Baertschiger RM, Dinauer C, Francis GL, Malek MM, Lautz TB, Aldrink JH, Grant C, Rhee DS, Ehrlich P, Dasgupta R, Abdessalam S; APSA Cancer Committee. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. J Pediatr Surg. 2020 Nov;55(11):2273-2283. doi: 10.1016/j.jpedsurg.2020.05.003. Epub 2020 May 11. PMID: 32553450.